Assay Detail
Functional
CHEMBL4841187
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 72 hrs by PrestoBlue reagent based assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Oral Anticancer 1,2-Bis(hydroxymethyl)benzo[<i>g</i>]pyrrolo[2,1-<i>a</i>]phthalazine Hybrids That Inhibit Angiogenesis and Induce DNA Cross-Links.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.86 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.85 |
| CHEMBL4879183 | — | — | 1 | 7.70 |
| CHEMBL4867439 | — | — | 1 | 7.22 |
| CHEMBL4871641 | — | — | 1 | 6.85 |
| CHEMBL4872568 | — | — | 1 | 6.72 |
| CHEMBL4874361 | — | — | 1 | 6.72 |
| CHEMBL4873164 | — | — | 1 | 6.51 |
| CHEMBL4854342 | — | — | 1 | 6.42 |
| CHEMBL4856371 | — | — | 1 | 6.38 |
| CHEMBL4869983 | — | — | 1 | 6.10 |
| CHEMBL4851847 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 1.41 | nM | 8.85 |
| CHEMBL4879183 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4867439 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4871641 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4872568 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4874361 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4873164 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4854342 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4856371 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4869983 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4851847 | — | IC50 | = | 950.0 | nM | 6.02 |