Assay Detail
Functional
CHEMBL4841191
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Cytotoxicity against human NCI-H520 cells assessed as reduction in cell viability incubated for 72 hrs by PrestoBlue reagent based assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H520 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Oral Anticancer 1,2-Bis(hydroxymethyl)benzo[<i>g</i>]pyrrolo[2,1-<i>a</i>]phthalazine Hybrids That Inhibit Angiogenesis and Induce DNA Cross-Links.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.60 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4879183 | — | — | 1 | 6.64 |
| CHEMBL4854342 | — | — | 1 | 6.00 |
| CHEMBL4872568 | — | — | 1 | 5.86 |
| CHEMBL4874361 | — | — | 1 | 5.85 |
| CHEMBL4869983 | — | — | 1 | 5.44 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 4.94 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4879183 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4854342 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4872568 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL4874361 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4869983 | — | IC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 36160.0 | nM | 4.44 |