Assay Detail
ADMET
CHEMBL4841230
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human EA.hy 926 cells assessed as reduction in cell viability incubated for 72 hrs by PrestoBlue reagent based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | EA.hy 926 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Oral Anticancer 1,2-Bis(hydroxymethyl)benzo[<i>g</i>]pyrrolo[2,1-<i>a</i>]phthalazine Hybrids That Inhibit Angiogenesis and Induce DNA Cross-Links.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.10 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4872568 | — | — | 1 | 5.54 |
| CHEMBL101253 | VATALANIB | 3.0 | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4872568 | — | IC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL101253 | VATALANIB | IC50 | = | 22320.0 | nM | 4.65 |