Assay Detail
Functional
CHEMBL4841562
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Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel somatostatin receptor subtype-2 agonists: Optimization for potency and risk mitigation of hERG and phospholipidosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 10.14 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4866325 | — | — | 1 | 10.89 |
| CHEMBL4872591 | — | — | 1 | 10.89 |
| CHEMBL4861425 | — | — | 1 | 10.89 |
| CHEMBL4849848 | — | — | 1 | 10.85 |
| CHEMBL4860633 | — | — | 1 | 10.82 |
| CHEMBL4873269 | — | — | 1 | 10.77 |
| CHEMBL4853282 | — | — | 1 | 10.72 |
| CHEMBL4858892 | — | — | 1 | 10.57 |
| CHEMBL1680 | OCTREOTIDE | 4.0 | 1 | 10.52 |
| CHEMBL4863880 | — | — | 1 | 10.52 |
| CHEMBL4845867 | — | — | 1 | 10.40 |
| CHEMBL4870834 | — | — | 1 | 10.39 |
| CHEMBL4862195 | — | — | 1 | 10.32 |
| CHEMBL4876263 | — | — | 1 | 10.11 |
| CHEMBL4851978 | — | — | 1 | 10.10 |
| CHEMBL4878917 | — | — | 1 | 10.09 |
| CHEMBL4854548 | — | — | 1 | 10.00 |
| CHEMBL4862497 | — | — | 1 | 9.92 |
| CHEMBL4862717 | — | — | 1 | 9.85 |
| CHEMBL4854239 | — | — | 1 | 9.68 |
| CHEMBL4856293 | — | — | 1 | 9.33 |
| CHEMBL4856084 | — | — | 1 | 9.23 |
| CHEMBL4878248 | — | — | 1 | 9.10 |
| CHEMBL4868777 | — | — | 1 | 9.00 |
| CHEMBL4845931 | — | — | 1 | 8.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4866325 | — | EC50 | = | 0.013 | nM | 10.89 |
| CHEMBL4872591 | — | EC50 | = | 0.013 | nM | 10.89 |
| CHEMBL4861425 | — | EC50 | = | 0.013 | nM | 10.89 |
| CHEMBL4849848 | — | EC50 | = | 0.014 | nM | 10.85 |
| CHEMBL4860633 | — | EC50 | = | 0.015 | nM | 10.82 |
| CHEMBL4873269 | — | EC50 | = | 0.017 | nM | 10.77 |
| CHEMBL4853282 | — | EC50 | = | 0.019 | nM | 10.72 |
| CHEMBL4858892 | — | EC50 | = | 0.027 | nM | 10.57 |
| CHEMBL1680 | OCTREOTIDE | EC50 | = | 0.03 | nM | 10.52 |
| CHEMBL4863880 | — | EC50 | = | 0.03 | nM | 10.52 |
| CHEMBL4845867 | — | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL4870834 | — | EC50 | = | 0.041 | nM | 10.39 |
| CHEMBL4862195 | — | EC50 | = | 0.048 | nM | 10.32 |
| CHEMBL4876263 | — | EC50 | = | 0.078 | nM | 10.11 |
| CHEMBL4851978 | — | EC50 | = | 0.08 | nM | 10.10 |
| CHEMBL4878917 | — | EC50 | = | 0.081 | nM | 10.09 |
| CHEMBL4854548 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4862497 | — | EC50 | = | 0.12 | nM | 9.92 |
| CHEMBL4862717 | — | EC50 | = | 0.14 | nM | 9.85 |
| CHEMBL4854239 | — | EC50 | = | 0.21 | nM | 9.68 |
| CHEMBL4856293 | — | EC50 | = | 0.47 | nM | 9.33 |
| CHEMBL4856084 | — | EC50 | = | 0.59 | nM | 9.23 |
| CHEMBL4878248 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4868777 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4845931 | — | EC50 | = | 3.7 | nM | 8.43 |