Assay Detail
Functional
CHEMBL4841584
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated with compound for 2 hrs followed by LPS stimulation measured after 18 hrs by gGriess reagent based assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Total Syntheses and Anti-inflammatory Activities of Syringin and Its Natural Analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.86 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.64 |
| CHEMBL3236505 | — | — | 1 | 4.84 |
| CHEMBL228183 | — | — | 1 | 4.81 |
| CHEMBL4874788 | — | — | 1 | 4.78 |
| CHEMBL250872 | SYRINGIN | — | 1 | 4.76 |
| CHEMBL3916405 | — | — | 1 | 4.73 |
| CHEMBL4859245 | — | — | 1 | 4.69 |
| CHEMBL4846998 | — | — | 1 | 4.60 |
| CHEMBL2332681 | DIHYDROSYRINGIN | — | 1 | - |
| CHEMBL4856262 | — | — | 1 | - |
| CHEMBL4861531 | — | — | 1 | - |
| CHEMBL4878502 | — | — | 1 | - |
| CHEMBL251059 | SINAPALDEHYDE GLUCOSIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3236505 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL228183 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL4874788 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL250872 | SYRINGIN | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL3916405 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL4859245 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL4846998 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL2332681 | DIHYDROSYRINGIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL4856262 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4861531 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4878502 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL251059 | SINAPALDEHYDE GLUCOSIDE | IC50 | > | 100000.0 | nM | - |