Assay Detail
Binding
CHEMBL4842271
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Inhibition of JNK1 in mouse RAW264.7 cells assessed as inhibition of c-Jun phosphorylation incubated for 30 mins by cellular assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase 8 (CHEMBL1795174) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of the c-Jun N-Terminal Kinase Inhibitor <b>CC-90001</b>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.06 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4862452 | — | — | 1 | 6.77 |
| CHEMBL4877655 | — | — | 1 | 6.68 |
| CHEMBL4878046 | — | — | 1 | 6.67 |
| CHEMBL4874549 | — | — | 1 | 6.46 |
| CHEMBL4847078 | — | — | 1 | 6.40 |
| CHEMBL4872066 | — | — | 1 | 6.26 |
| CHEMBL4853125 | — | — | 1 | 6.24 |
| CHEMBL1950289 | TANZISERTIB | 2.0 | 1 | 5.95 |
| CHEMBL4861369 | — | — | 1 | 5.84 |
| CHEMBL4874419 | — | — | 1 | 5.75 |
| CHEMBL4848290 | — | — | 1 | 5.62 |
| CHEMBL4848796 | — | — | 1 | 5.17 |
| CHEMBL4852680 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4862452 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4877655 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4878046 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL4874549 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4847078 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4872066 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4853125 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL1950289 | TANZISERTIB | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL4861369 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL4874419 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL4848290 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL4848796 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4852680 | — | IC50 | = | 10100.0 | nM | 5.00 |