Assay Detail
Binding
CHEMBL4842296
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of endogenous Huntingtin protein (unknown origin) incubated for overnight in presence of MW1/MAB2166 monoclonal antibody by ELISA-based MSD electrochemiluminescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Substituted Heteroaryl Compounds for Treating Huntington's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.71 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4875017 | — | — | 1 | 8.80 |
| CHEMBL4878942 | — | — | 1 | 8.77 |
| CHEMBL4863336 | — | — | 1 | 8.68 |
| CHEMBL4847156 | — | — | 1 | 8.68 |
| CHEMBL4867927 | — | — | 1 | 8.66 |
| CHEMBL4859053 | — | — | 1 | 8.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4875017 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4878942 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4863336 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4847156 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4867927 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4859053 | — | IC50 | = | 2.3 | nM | 8.64 |