Assay Detail
Functional
CHEMBL4843159
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-COV 2 infected in human Caco-2 cells assessed as inhibition of viral replication at MOI of 0.01 and incubated after 2 hrs post infection for 48 hrs by immunodetection assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Caco-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.62 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | 4.0 | 1 | 8.00 |
| CHEMBL4848338 | — | — | 1 | 5.23 |
| CHEMBL4845724 | — | — | 1 | - |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | - |
| CHEMBL4847429 | — | — | 1 | - |
| CHEMBL590799 | CAMOSTAT | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4848338 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4845724 | — | IC50 | - | — | - | |
| CHEMBL1643 | RIBAVIRIN | IC50 | - | — | - | |
| CHEMBL4847429 | — | IC50 | - | — | - | |
| CHEMBL590799 | CAMOSTAT | IC50 | - | — | - |