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Assay Detail

CHEMBL4843199

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Binding
Agonist activity at human AMY3R (CT+RAMP3) expressed in Hollex1 cells incubated for 3 hrs by luminescence assay
ChEMBL ↗
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type Hollex1
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Development of Cagrilintide, a Long-Acting Amylin Analogue.
Kruse T, Hansen JL, Dahl K, Schäffer L, Sensfuss U, Poulsen C, Schlein M, Hansen AMK, Jeppesen CB, Dornonville de la Cour C, Clausen TR, Johansson E, Fulle S, Skyggebjerg RB, Raun K.
J Med Chem (2021) 64 : 11183 -11194
PubMed 34288673 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 29 9.99 10.31

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4860423 — — 1 10.31
CHEMBL4877066 — — 1 10.21
CHEMBL4847769 — — 1 10.16
CHEMBL4857768 — — 1 10.14
CHEMBL4859695 — — 1 10.13
CHEMBL4868506 — — 1 10.13
CHEMBL4865624 — — 1 10.12
CHEMBL4855949 — — 1 10.11
CHEMBL4866960 — — 1 10.11
CHEMBL4853852 — — 1 10.08
CHEMBL4853250 — — 1 10.08
CHEMBL4860327 — — 1 10.04
CHEMBL4861227 — — 1 10.02
CHEMBL4852769 — — 1 10.02
CHEMBL4863501 — — 1 10.00
CHEMBL4859757 — — 1 9.99
CHEMBL4863815 — — 1 9.99
CHEMBL4846668 — — 1 9.97
CHEMBL4856338 — — 1 9.96
CHEMBL4872163 — — 1 9.92
CHEMBL4863929 — — 1 9.90
CHEMBL4874471 — — 1 9.89
CHEMBL4860505 — — 1 9.85
CHEMBL4847968 — — 1 9.84
CHEMBL4873689 — — 1 9.78
CHEMBL4854371 — — 1 9.53
CHEMBL4856671 — — 1 9.42
CHEMBL2103758 PRAMLINTIDE 4.0 1 -
CHEMBL3989767 CALCITONIN SALMON 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4860423 — EC50 = 0.049 nM 10.31
CHEMBL4877066 — EC50 = 0.061 nM 10.21
CHEMBL4847769 — EC50 = 0.069 nM 10.16
CHEMBL4857768 — EC50 = 0.072 nM 10.14
CHEMBL4859695 — EC50 = 0.074 nM 10.13
CHEMBL4868506 — EC50 = 0.074 nM 10.13
CHEMBL4865624 — EC50 = 0.076 nM 10.12
CHEMBL4855949 — EC50 = 0.077 nM 10.11
CHEMBL4866960 — EC50 = 0.078 nM 10.11
CHEMBL4853852 — EC50 = 0.083 nM 10.08
CHEMBL4853250 — EC50 = 0.083 nM 10.08
CHEMBL4860327 — EC50 = 0.091 nM 10.04
CHEMBL4861227 — EC50 = 0.095 nM 10.02
CHEMBL4852769 — EC50 = 0.096 nM 10.02
CHEMBL4863501 — EC50 = 0.1 nM 10.00
CHEMBL4859757 — EC50 = 0.102 nM 9.99
CHEMBL4863815 — EC50 = 0.102 nM 9.99
CHEMBL4846668 — EC50 = 0.107 nM 9.97
CHEMBL4856338 — EC50 = 0.111 nM 9.96
CHEMBL4872163 — EC50 = 0.121 nM 9.92
CHEMBL4863929 — EC50 = 0.125 nM 9.90
CHEMBL4874471 — EC50 = 0.129 nM 9.89
CHEMBL4860505 — EC50 = 0.14 nM 9.85
CHEMBL4847968 — EC50 = 0.145 nM 9.84
CHEMBL4873689 — EC50 = 0.166 nM 9.78
CHEMBL4854371 — EC50 = 0.297 nM 9.53
CHEMBL4856671 — EC50 = 0.377 nM 9.42
CHEMBL2103758 PRAMLINTIDE EC50 = 0.005 nM -
CHEMBL3989767 CALCITONIN SALMON EC50 = 0.002 nM -