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Compound Detail

CHEMBL3989767

CALCITONIN SALMON
💊 Approved Drug
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💊 Approved Drug
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ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL3989767
Name CALCITONIN SALMON
Phase Approved
Structure Type BOTH
InChI Key BBBFJLBPOGFECG-VJVYQDLKSA-N
Therapeutic ✓ Yes

Known Names

Calcimar Calcitonin (salmon synthetic) Calcitonin salmon Calcitonin salmon recombinant Calcitonin-salmon Forcaltonin Fortical Miacalcin Recombinant salmon calcitonin Scalcitonin
7
Targets
22
Activities
2
Assay Types
0
PK Parameters
16
Publications
10
Known Names
8
Indications
1
Mechanisms

Molecular Properties

3431.9
MW (Da)

Drug Information

Molecule Type Protein
First Approval 1978
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Parenteral Topical

Flags

Natural Product
USAN Stem calci-; sal-

Extended Properties

Molecular Formula C145H240N44O48S2
MW 3431.91

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Calcitonin receptor agonist AGONIST Calcitonin receptor ✓ ✓

Indications

Bone Resorption Hypercalcemia Osteitis Deformans Osteoporosis, Postmenopausal Parathyroid Diseases Menopause Osteoporosis Bone Diseases, Metabolic

ATC Classification

H05BA01
calcitonin (salmon synthetic)
Level 1: SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
Level 2: CALCIUM HOMEOSTASIS

Activity Summary

EC50 14 meas. best 10.87
IC50 8 meas. best 10.55

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Amylin receptor AMY3; CALCR/RAMP3
CHEMBL2111190
 EC50 10.87 10.87 0.0 1
Amylin receptor AMY3; CALCR/RAMP3
CHEMBL2109235
 IC50 10.55 10.55 0.0 1
Unchecked
CHEMBL612545
 IC50 10.55 10.325 0.0 4
Calcitonin receptor
CHEMBL2204
 IC50 10.52 10.52 0.0 1
Calcitonin receptor
CHEMBL1832
 IC50 10.18 10.18 0.1 1
Amylin receptor AMY3; CALCR/RAMP3
CHEMBL2111190
 IC50 10.05 10.05 0.1 1
HEK293
CHEMBL614818
 EC50 8.52 8.52 3.0 1
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1
CHEMBL2107838
 EC50 6.41 6.41 389.1 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Amylin receptor AMY3; CALCR/RAMP3 EC50 = 0.01349 nM 10.87 Agonist activity at human AMY3R complex of CTR/RAMP3 transduced in human HeLa ce... 38960379
Unchecked IC50 = 0.028 nM 10.55 Displacement of [125I]-amylin from rat AMY3R (CTR+RAMP3) expressed in BHK-13 cel... 34288673
Amylin receptor AMY3; CALCR/RAMP3 IC50 = 0.028 nM 10.55 Displacement of 125I-rat amylin from rat AMY3R complex of CTR/RAMP3 expressed in... 38960379
Unchecked IC50 = 0.03 nM 10.52 Displacement of [125I]-calcitonin from rat calcitonin receptor expressed in tk-t... 34288673
Calcitonin receptor IC50 = 0.03 nM 10.52 Displacement of 125I-Calcitonin from rat CTR expressed in Baby hamster kidney ce... 38960379
Unchecked IC50 = 0.066 nM 10.18 Displacement of [125I]-calcitonin from human calcitonin receptor expressed in tk... 34288673
Calcitonin receptor IC50 = 0.066 nM 10.18 Displacement of 125I-Calcitonin from human CTR expressed in Baby hamster kidney ... 38960379
Unchecked IC50 = 0.089 nM 10.05 Displacement of [125I]-amylin from human AMY3R (CTR+RAMP3) expressed in BHK-13 c... 34288673
Amylin receptor AMY3; CALCR/RAMP3 IC50 = 0.089 nM 10.05 Displacement of 125I-rat amylin from human AMY3R complex of CTR/RAMP3 expressed ... 38960379
HEK293 EC50 = 3.0 nM 8.52 In vitro cAMP accumulation in HEK 293 cells. 14980655
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 EC50 = 389.05 nM 6.41 Agonist activity at human CGRPR complex of CRLR/RAMP1 transduced in human HeLa c... 38960379

Literature References

PubMed DOI Target Context # Activities
34288673 10.1021/acs.jmedchem.1c00565 Unchecked 12
15646539 10.1016/s0399-8320(04)95062-2 Unchecked 11
15646539 10.1016/s0399-8320(04)95062-2 NON-PROTEIN TARGET 8
38960379 10.1021/acs.jmedchem.4c00022 Amylin receptor AMY3; CALCR/RAMP3 5
38960379 10.1021/acs.jmedchem.4c00022 Calcitonin receptor 5
38960379 10.1021/acs.jmedchem.4c00022 Unchecked 4
14980655 10.1016/j.bmcl.2003.12.071 HEK293 2
26948801 10.1016/j.drudis.2016.02.015 Homo sapiens 2
3397998 10.1021/jm00403a019 Rattus norvegicus 1
15743175 10.1021/jm040830d Rattus norvegicus 1
15743175 10.1021/jm040830d Rattus 1
38960379 10.1021/acs.jmedchem.4c00022 Amylin receptor AMY1, CALCR/RAMP1 1
38960379 10.1021/acs.jmedchem.4c00022 Amylin receptor AMY2; CALCR/RAMP2 1
38960379 10.1021/acs.jmedchem.4c00022 Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 1
38960379 10.1021/acs.jmedchem.4c00022 Adrenomedullin receptor AM1; CALCRL/RAMP2 1
38960379 10.1021/acs.jmedchem.4c00022 Adrenomedullin receptor, AM2; CALCRL/RAMP3 1

Data from ChEMBL 36 via Core Engine