Assay Detail
Binding
CHEMBL5526174
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Displacement of 125I-rat amylin from rat AMY3R complex of CTR/RAMP3 expressed in Baby hamster kidney cell membrane incubated for 120 mins by SPA method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Kidney |
| Cell Type | Baby hamster kidney cell |
| Subcellular | Membrane |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Amylin receptor AMY3; CALCR/RAMP3 (CHEMBL2109235) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
NN1213 - A Potent, Long-Acting, and Selective Analog of Human Amylin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 9.22 | 10.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3989767 | CALCITONIN SALMON | 4.0 | 1 | 10.55 |
| CHEMBL2103758 | PRAMLINTIDE | 4.0 | 1 | 9.91 |
| CHEMBL5567107 | — | — | 1 | 9.75 |
| CHEMBL5554990 | — | — | 1 | 9.69 |
| CHEMBL5567446 | — | — | 1 | 9.66 |
| CHEMBL5567377 | — | — | 1 | 9.54 |
| CHEMBL5566450 | — | — | 1 | 9.43 |
| CHEMBL5556440 | — | — | 1 | 9.35 |
| CHEMBL5561117 | — | — | 1 | 9.04 |
| CHEMBL5568414 | — | — | 1 | 9.00 |
| CHEMBL5568431 | — | — | 1 | 8.93 |
| CHEMBL5560524 | — | — | 1 | 8.91 |
| CHEMBL5560328 | — | — | 1 | 8.89 |
| CHEMBL5568471 | — | — | 1 | 8.89 |
| CHEMBL5566453 | — | — | 1 | 8.77 |
| CHEMBL5568545 | — | — | 1 | 8.75 |
| CHEMBL5568143 | — | — | 1 | 8.52 |
| CHEMBL5565993 | — | — | 1 | 8.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3989767 | CALCITONIN SALMON | IC50 | = | 0.028 | nM | 10.55 |
| CHEMBL2103758 | PRAMLINTIDE | IC50 | = | 0.122 | nM | 9.91 |
| CHEMBL5567107 | — | IC50 | = | 0.176 | nM | 9.75 |
| CHEMBL5554990 | — | IC50 | = | 0.203 | nM | 9.69 |
| CHEMBL5567446 | — | IC50 | = | 0.217 | nM | 9.66 |
| CHEMBL5567377 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL5566450 | — | IC50 | = | 0.372 | nM | 9.43 |
| CHEMBL5556440 | — | IC50 | = | 0.449 | nM | 9.35 |
| CHEMBL5561117 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL5568414 | — | IC50 | = | 1.002 | nM | 9.00 |
| CHEMBL5568431 | — | IC50 | = | 1.171 | nM | 8.93 |
| CHEMBL5560524 | — | IC50 | = | 1.24 | nM | 8.91 |
| CHEMBL5560328 | — | IC50 | = | 1.293 | nM | 8.89 |
| CHEMBL5568471 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5566453 | — | IC50 | = | 1.715 | nM | 8.77 |
| CHEMBL5568545 | — | IC50 | = | 1.768 | nM | 8.75 |
| CHEMBL5568143 | — | IC50 | = | 3.006 | nM | 8.52 |
| CHEMBL5565993 | — | IC50 | = | 4.69 | nM | 8.33 |