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Target Snapshot

CHEMBL2204 Target Snapshot

Calcitonin receptor · SINGLE PROTEIN · Rattus norvegicus

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33Compounds
4Assays
3Approved Drugs
42.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P32214. Use UniProt P32214 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P32214 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Calcitonin receptor as ChEMBL target CHEMBL2204, mapped to UniProt P32214. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Calcitonin receptor
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL2204
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P32214
Calcitonin receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Calcitonin receptor is the right protein anchor across sources, using UniProt P32214 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameCalcitonin receptor
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtP32214
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCalcitonin receptor
UniProt AccessionP32214
Component TypeProtein
Sequence Length516 aa

Calcitonin receptor

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Calcitonin receptor, mapped to UniProt P32214. Sequence length is 516 aa.

Mapped IDP32214
Review nameCalcitonin receptor
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

3
Approved
Assay Mix

Activity Type Distribution

IC5032.0
EC5010.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3989767 10.52 IC50 0.03 Approved
CHEMBL2369912 9.74 IC50 0.18 Preclinical
CHEMBL2369886 9.6 IC50 0.249 Preclinical
CHEMBL2369895 9.49 IC50 0.326 Preclinical
CHEMBL2369907 9.42 IC50 0.377 Preclinical
CHEMBL2369915 9.39 IC50 0.408 Preclinical
CHEMBL2103758 8.74 EC50 1.822 Approved
CHEMBL2369893 8.27 IC50 5.39 Preclinical
CHEMBL2103758 8.23 IC50 5.834 Approved
CHEMBL5567107 8.22 IC50 5.976 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
2
5.5
3
6.0
5
6.5
12
7.0
5
7.5
4
8.0
1
8.5
3
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

PRAMLINTIDE
CHEMBL2103758
Approved 2005
Properties Compare Identifier
CALCITONIN SALMON
CHEMBL3989767
Approved 1978
Properties Compare Identifier
Assay Landscape

Assay Landscape

4
Total Assays
29
Tested Compounds
2
Assay Types
Binding — 3 assays, 29 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 11 8.0
cell membrane format 1 18 7.5
Functional — 1 assays, 10 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 10 7.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine