Assay Detail
Binding
CHEMBL5526171
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 125I-rat amylin from human AMY3R complex of CTR/RAMP3 expressed in Baby hamster kidney cell membrane incubated for 120 mins by SPA method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Kidney |
| Cell Type | Baby hamster kidney cell |
| Subcellular | Membrane |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Amylin receptor AMY3; CALCR/RAMP3 (CHEMBL2111190) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
NN1213 - A Potent, Long-Acting, and Selective Analog of Human Amylin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 9.24 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3989767 | CALCITONIN SALMON | 4.0 | 1 | 10.05 |
| CHEMBL5567107 | — | — | 1 | 10.00 |
| CHEMBL2103758 | PRAMLINTIDE | 4.0 | 1 | 9.94 |
| CHEMBL5566450 | — | — | 1 | 9.67 |
| CHEMBL5554990 | — | — | 1 | 9.46 |
| CHEMBL5567446 | — | — | 1 | 9.45 |
| CHEMBL5560328 | — | — | 1 | 9.31 |
| CHEMBL5567377 | — | — | 1 | 9.25 |
| CHEMBL5568431 | — | — | 1 | 9.23 |
| CHEMBL5568545 | — | — | 1 | 9.18 |
| CHEMBL5556440 | — | — | 1 | 9.13 |
| CHEMBL5561117 | — | — | 1 | 9.05 |
| CHEMBL5568414 | — | — | 1 | 8.95 |
| CHEMBL5568471 | — | — | 1 | 8.95 |
| CHEMBL5566453 | — | — | 1 | 8.94 |
| CHEMBL5568143 | — | — | 1 | 8.94 |
| CHEMBL5560524 | — | — | 1 | 8.56 |
| CHEMBL5565993 | — | — | 1 | 8.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3989767 | CALCITONIN SALMON | IC50 | = | 0.089 | nM | 10.05 |
| CHEMBL5567107 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL2103758 | PRAMLINTIDE | IC50 | = | 0.114 | nM | 9.94 |
| CHEMBL5566450 | — | IC50 | = | 0.213 | nM | 9.67 |
| CHEMBL5554990 | — | IC50 | = | 0.344 | nM | 9.46 |
| CHEMBL5567446 | — | IC50 | = | 0.355 | nM | 9.45 |
| CHEMBL5560328 | — | IC50 | = | 0.484 | nM | 9.31 |
| CHEMBL5567377 | — | IC50 | = | 0.561 | nM | 9.25 |
| CHEMBL5568431 | — | IC50 | = | 0.589 | nM | 9.23 |
| CHEMBL5568545 | — | IC50 | = | 0.662 | nM | 9.18 |
| CHEMBL5556440 | — | IC50 | = | 0.745 | nM | 9.13 |
| CHEMBL5561117 | — | IC50 | = | 0.885 | nM | 9.05 |
| CHEMBL5568414 | — | IC50 | = | 1.125 | nM | 8.95 |
| CHEMBL5568471 | — | IC50 | = | 1.121 | nM | 8.95 |
| CHEMBL5566453 | — | IC50 | = | 1.139 | nM | 8.94 |
| CHEMBL5568143 | — | IC50 | = | 1.138 | nM | 8.94 |
| CHEMBL5560524 | — | IC50 | = | 2.746 | nM | 8.56 |
| CHEMBL5565993 | — | IC50 | = | 5.095 | nM | 8.29 |