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Assay Detail

CHEMBL4843205

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]-amylin from human AMY3R (CTR+RAMP3) expressed in BHK-13 cells measured after 120 mins by scintillation proximity assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type BHK-13
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Development of Cagrilintide, a Long-Acting Amylin Analogue.
Kruse T, Hansen JL, Dahl K, Schäffer L, Sensfuss U, Poulsen C, Schlein M, Hansen AMK, Jeppesen CB, Dornonville de la Cour C, Clausen TR, Johansson E, Fulle S, Skyggebjerg RB, Raun K.
J Med Chem (2021) 64 : 11183 -11194
PubMed 34288673 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 9.49 10.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4866960 1 10.28
CHEMBL3989767 CALCITONIN SALMON 4.0 1 10.05
CHEMBL2103758 PRAMLINTIDE 4.0 1 9.94
CHEMBL4853852 1 9.86
CHEMBL4860423 1 9.77
CHEMBL4877066 1 9.73
CHEMBL4872163 1 9.72
CHEMBL4865624 1 9.67
CHEMBL4868506 1 9.67
CHEMBL4860327 1 9.53
CHEMBL4863501 1 9.46
CHEMBL4859757 1 9.45
CHEMBL4853250 1 9.30
CHEMBL4859695 1 9.14
CHEMBL4855949 1 9.09
CHEMBL4847968 1 8.97
CHEMBL4863815 1 8.96
CHEMBL4861227 1 8.89
CHEMBL4863929 1 8.87

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4866960 IC50 = 0.052 nM 10.28
CHEMBL3989767 CALCITONIN SALMON IC50 = 0.089 nM 10.05
CHEMBL2103758 PRAMLINTIDE IC50 = 0.114 nM 9.94
CHEMBL4853852 IC50 = 0.137 nM 9.86
CHEMBL4860423 IC50 = 0.17 nM 9.77
CHEMBL4877066 IC50 = 0.186 nM 9.73
CHEMBL4872163 IC50 = 0.192 nM 9.72
CHEMBL4865624 IC50 = 0.213 nM 9.67
CHEMBL4868506 IC50 = 0.216 nM 9.67
CHEMBL4860327 IC50 = 0.293 nM 9.53
CHEMBL4863501 IC50 = 0.35 nM 9.46
CHEMBL4859757 IC50 = 0.359 nM 9.45
CHEMBL4853250 IC50 = 0.499 nM 9.30
CHEMBL4859695 IC50 = 0.723 nM 9.14
CHEMBL4855949 IC50 = 0.818 nM 9.09
CHEMBL4847968 IC50 = 1.072 nM 8.97
CHEMBL4863815 IC50 = 1.107 nM 8.96
CHEMBL4861227 IC50 = 1.295 nM 8.89
CHEMBL4863929 IC50 = 1.348 nM 8.87