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Assay Detail

CHEMBL5526175

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of 125I-Calcitonin from rat CTR expressed in Baby hamster kidney cell membrane incubated for 120 mins by SPA method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Kidney
Cell Type Baby hamster kidney cell
Subcellular Membrane
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Calcitonin receptor (CHEMBL2204)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

NN1213 - A Potent, Long-Acting, and Selective Analog of Human Amylin.
Dahl K, Raun K, Hansen JL, Poulsen C, de la Cour CD, Clausen TR, Hansen AMK, John LM, Plesner A, Sun G, Schlein M, Skyggebjerg RB, Kruse T.
J Med Chem (2024) 67 : 11688 -11700
PubMed 38960379 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 7.47 10.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3989767 CALCITONIN SALMON 4.0 1 10.52
CHEMBL2103758 PRAMLINTIDE 4.0 1 8.23
CHEMBL5567107 1 8.22
CHEMBL5568414 1 8.12
CHEMBL5554990 1 7.77
CHEMBL5566450 1 7.49
CHEMBL5556440 1 7.30
CHEMBL5560328 1 7.30
CHEMBL5568431 1 7.29
CHEMBL5561117 1 7.25
CHEMBL5560524 1 7.15
CHEMBL5566453 1 7.05
CHEMBL5568545 1 7.02
CHEMBL5567446 1 7.01
CHEMBL5568471 1 6.98
CHEMBL5567377 1 6.87
CHEMBL5568143 1 6.46
CHEMBL5565993 1 6.45

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3989767 CALCITONIN SALMON IC50 = 0.03 nM 10.52
CHEMBL2103758 PRAMLINTIDE IC50 = 5.834 nM 8.23
CHEMBL5567107 IC50 = 5.976 nM 8.22
CHEMBL5568414 IC50 = 7.545 nM 8.12
CHEMBL5554990 IC50 = 17.11 nM 7.77
CHEMBL5566450 IC50 = 32.74 nM 7.49
CHEMBL5556440 IC50 = 50.05 nM 7.30
CHEMBL5560328 IC50 = 49.81 nM 7.30
CHEMBL5568431 IC50 = 51.41 nM 7.29
CHEMBL5561117 IC50 = 55.64 nM 7.25
CHEMBL5560524 IC50 = 71.02 nM 7.15
CHEMBL5566453 IC50 = 89.17 nM 7.05
CHEMBL5568545 IC50 = 96.44 nM 7.02
CHEMBL5567446 IC50 = 96.92 nM 7.01
CHEMBL5568471 IC50 = 105.57 nM 6.98
CHEMBL5567377 IC50 = 134.99 nM 6.87
CHEMBL5568143 IC50 = 349.7 nM 6.46
CHEMBL5565993 IC50 = 355.75 nM 6.45