Assay Detail
Functional
CHEMBL5526193
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human CGRPR complex of CRLR/RAMP1 transduced in human HeLa cells by cAMP assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 (CHEMBL2107838) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
NN1213 - A Potent, Long-Acting, and Selective Analog of Human Amylin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.72 | 7.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103758 | PRAMLINTIDE | 4.0 | 1 | 7.63 |
| CHEMBL5567377 | — | — | 1 | 6.57 |
| CHEMBL3989767 | CALCITONIN SALMON | 4.0 | 1 | 6.41 |
| CHEMBL4802169 | CAGRILINTIDE | 3.0 | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103758 | PRAMLINTIDE | EC50 | = | 23.44 | nM | 7.63 |
| CHEMBL5567377 | — | EC50 | = | 269.15 | nM | 6.57 |
| CHEMBL3989767 | CALCITONIN SALMON | EC50 | = | 389.05 | nM | 6.41 |
| CHEMBL4802169 | CAGRILINTIDE | EC50 | = | 562.34 | nM | 6.25 |