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Assay Detail

CHEMBL4843200

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Binding
Agonist activity at human calcitonin receptor expressed in BHK570 cells assessed as increase in intracellular cAMP concentration incubated for 3 hrs in absence of albumin by CRE luciferase reporter gene assay
ChEMBL ↗
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type BHK570
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Development of Cagrilintide, a Long-Acting Amylin Analogue.
Kruse T, Hansen JL, Dahl K, Schäffer L, Sensfuss U, Poulsen C, Schlein M, Hansen AMK, Jeppesen CB, Dornonville de la Cour C, Clausen TR, Johansson E, Fulle S, Skyggebjerg RB, Raun K.
J Med Chem (2021) 64 : 11183 -11194
PubMed 34288673 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 29 9.65 10.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4877066 — — 1 10.28
CHEMBL4860423 — — 1 10.21
CHEMBL4860327 — — 1 10.17
CHEMBL2103758 PRAMLINTIDE 4.0 1 10.15
CHEMBL4872163 — — 1 9.97
CHEMBL4863929 — — 1 9.93
CHEMBL4853250 — — 1 9.90
CHEMBL4853852 — — 1 9.89
CHEMBL4855949 — — 1 9.89
CHEMBL4868506 — — 1 9.87
CHEMBL4847968 — — 1 9.83
CHEMBL4852769 — — 1 9.80
CHEMBL4859757 — — 1 9.78
CHEMBL4873689 — — 1 9.74
CHEMBL4859695 — — 1 9.70
CHEMBL4874471 — — 1 9.69
CHEMBL4846668 — — 1 9.66
CHEMBL4854371 — — 1 9.46
CHEMBL4856338 — — 1 9.42
CHEMBL4863815 — — 1 9.41
CHEMBL4847769 — — 1 9.40
CHEMBL4857768 — — 1 9.39
CHEMBL4863501 — — 1 9.35
CHEMBL4866960 — — 1 9.22
CHEMBL4856671 — — 1 9.18
CHEMBL4861227 — — 1 9.02
CHEMBL4860505 — — 1 8.97
CHEMBL4865624 — — 1 8.90
CHEMBL3989767 CALCITONIN SALMON 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4877066 — EC50 = 0.052 nM 10.28
CHEMBL4860423 — EC50 = 0.062 nM 10.21
CHEMBL4860327 — EC50 = 0.067 nM 10.17
CHEMBL2103758 PRAMLINTIDE EC50 = 0.07 nM 10.15
CHEMBL4872163 — EC50 = 0.107 nM 9.97
CHEMBL4863929 — EC50 = 0.117 nM 9.93
CHEMBL4853250 — EC50 = 0.125 nM 9.90
CHEMBL4853852 — EC50 = 0.128 nM 9.89
CHEMBL4855949 — EC50 = 0.129 nM 9.89
CHEMBL4868506 — EC50 = 0.136 nM 9.87
CHEMBL4847968 — EC50 = 0.147 nM 9.83
CHEMBL4852769 — EC50 = 0.157 nM 9.80
CHEMBL4859757 — EC50 = 0.165 nM 9.78
CHEMBL4873689 — EC50 = 0.18 nM 9.74
CHEMBL4859695 — EC50 = 0.2 nM 9.70
CHEMBL4874471 — EC50 = 0.205 nM 9.69
CHEMBL4846668 — EC50 = 0.218 nM 9.66
CHEMBL4854371 — EC50 = 0.347 nM 9.46
CHEMBL4856338 — EC50 = 0.379 nM 9.42
CHEMBL4863815 — EC50 = 0.391 nM 9.41
CHEMBL4847769 — EC50 = 0.398 nM 9.40
CHEMBL4857768 — EC50 = 0.407 nM 9.39
CHEMBL4863501 — EC50 = 0.447 nM 9.35
CHEMBL4866960 — EC50 = 0.608 nM 9.22
CHEMBL4856671 — EC50 = 0.657 nM 9.18
CHEMBL4861227 — EC50 = 0.961 nM 9.02
CHEMBL4860505 — EC50 = 1.081 nM 8.97
CHEMBL4865624 — EC50 = 1.244 nM 8.90
CHEMBL3989767 CALCITONIN SALMON EC50 = 0.003 nM -