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Assay Detail

CHEMBL4843380

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Binding
Inhibition of DENV2 NS2B-NS3 protease
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism dengue virus type 2
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Genome polyprotein (CHEMBL5980)
Type SINGLE PROTEIN
Organism dengue virus type 2

Publication

Amidoxime prodrugs convert to potent cell-active multimodal inhibitors of the dengue virus protease.
Swarbrick C, Zogali V, Chan KWK, Kiousis D, Gwee CP, Wang S, Lescar J, Luo D, von Itzstein M, Matsoukas MT, Panagiotakopoulos G, Vasudevan SG, Rassias G.
Eur J Med Chem (2021) 224 : 113695 -113695
PubMed 34298282 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.32 5.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4446364 1 5.57
CHEMBL4854366 1 5.54
CHEMBL4879110 1 5.51
CHEMBL4568823 1 5.35
CHEMBL4868241 1 5.18
CHEMBL4860508 1 5.06
CHEMBL4870296 1 5.01
CHEMBL4871225 1 -
CHEMBL4878425 1 -
CHEMBL4853799 1 -
CHEMBL4864411 1 -
CHEMBL4850198 1 -
CHEMBL4857319 1 -
CHEMBL4853295 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4446364 IC50 = 2710.0 nM 5.57
CHEMBL4854366 IC50 = 2900.0 nM 5.54
CHEMBL4879110 IC50 = 3100.0 nM 5.51
CHEMBL4568823 IC50 = 4500.0 nM 5.35
CHEMBL4868241 IC50 = 6600.0 nM 5.18
CHEMBL4860508 IC50 = 8800.0 nM 5.06
CHEMBL4870296 IC50 = 9800.0 nM 5.01
CHEMBL4871225 IC50 = 121000.0 nM -
CHEMBL4878425 IC50 - -
CHEMBL4853799 IC50 - -
CHEMBL4864411 IC50 - -
CHEMBL4850198 IC50 - -
CHEMBL4857319 IC50 - -
CHEMBL4853295 IC50 - -