Assay Detail
Binding
CHEMBL4843953
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Inhibition of Schistosoma mansoni HDAC8 using Fluor de Lys as substrate incubated for 90 mins by fluorescence method
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Schistosoma mansoni |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.53 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4855490 | — | — | 1 | 7.00 |
| CHEMBL4867041 | — | — | 1 | 7.00 |
| CHEMBL4853162 | — | — | 1 | 7.00 |
| CHEMBL4849600 | — | — | 1 | 6.96 |
| CHEMBL4852163 | — | — | 1 | 6.96 |
| CHEMBL4870162 | — | — | 1 | 6.85 |
| CHEMBL4870316 | — | — | 1 | 6.82 |
| CHEMBL4870946 | — | — | 1 | 6.80 |
| CHEMBL4850958 | — | — | 1 | 6.77 |
| CHEMBL4874213 | — | — | 1 | 6.75 |
| CHEMBL4846424 | — | — | 1 | 6.75 |
| CHEMBL4853828 | — | — | 1 | 6.70 |
| CHEMBL4868510 | — | — | 1 | 6.68 |
| CHEMBL4865911 | — | — | 1 | 6.66 |
| CHEMBL4847326 | — | — | 1 | 6.57 |
| CHEMBL4876103 | — | — | 1 | 6.55 |
| CHEMBL3800394 | — | — | 1 | 6.54 |
| CHEMBL4866890 | — | — | 1 | 6.54 |
| CHEMBL4095643 | — | — | 1 | 6.51 |
| CHEMBL4850091 | — | — | 1 | 6.50 |
| CHEMBL4877604 | — | — | 1 | 6.50 |
| CHEMBL4878820 | — | — | 1 | 6.48 |
| CHEMBL4867661 | — | — | 1 | 6.48 |
| CHEMBL4065863 | — | — | 1 | 6.48 |
| CHEMBL4093480 | — | — | 1 | 6.48 |
| CHEMBL4857763 | — | — | 1 | 6.40 |
| CHEMBL4847732 | — | — | 1 | 6.37 |
| CHEMBL2170177 | — | — | 1 | 6.36 |
| CHEMBL4869895 | — | — | 1 | 6.35 |
| CHEMBL4851537 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4855490 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4853162 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4867041 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4849600 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4852163 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4870162 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4870316 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4870946 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4850958 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4846424 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4874213 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4853828 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4868510 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4865911 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4847326 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4876103 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3800394 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4866890 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4095643 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4877604 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4850091 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4878820 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4867661 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4065863 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4093480 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4857763 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4847732 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL2170177 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4869895 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4851537 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4872247 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4852733 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4876086 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL4869825 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4872326 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL4846516 | — | IC50 | = | 2080.0 | nM | 5.68 |