Assay Detail
Binding
CHEMBL4844259
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Inhibition of human recombinant AChE using acetylthiocholine iodide as a substrate preincubated for 20 mins followed by substrate addition by spectrophotometric analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.70 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4854913 | — | — | 1 | 9.39 |
| CHEMBL4848527 | — | — | 1 | 9.20 |
| CHEMBL140476 | HUPRINE Y | — | 1 | 8.97 |
| CHEMBL4872514 | — | — | 1 | 8.90 |
| CHEMBL4866930 | — | — | 1 | 8.74 |
| CHEMBL4862716 | — | — | 1 | 8.62 |
| CHEMBL4863615 | — | — | 1 | 8.62 |
| CHEMBL4859103 | — | — | 1 | 8.59 |
| CHEMBL3304306 | — | — | 1 | 8.44 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.57 |
| CHEMBL164 | MYRICETIN | — | 1 | - |
| CHEMBL345124 | PROPIDIUM | — | 1 | - |
| CHEMBL3545559 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4854913 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL4848527 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL140476 | HUPRINE Y | IC50 | = | 1.07 | nM | 8.97 |
| CHEMBL4872514 | — | IC50 | = | 1.25 | nM | 8.90 |
| CHEMBL4866930 | — | IC50 | = | 1.82 | nM | 8.74 |
| CHEMBL4862716 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4863615 | — | IC50 | = | 2.39 | nM | 8.62 |
| CHEMBL4859103 | — | IC50 | = | 2.57 | nM | 8.59 |
| CHEMBL3304306 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 26.8 | nM | 7.57 |
| CHEMBL164 | MYRICETIN | IC50 | - | — | - | |
| CHEMBL345124 | PROPIDIUM | IC50 | - | — | - | |
| CHEMBL3545559 | — | IC50 | - | — | - |