Assay Detail
Binding
CHEMBL4844260
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Inhibition of human serum BChE using butyrylthiocholine iodide as a substrate preincubated for 20 mins followed by substrate addition by spectrophotometric analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Serum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.88 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4866930 | — | — | 1 | 7.50 |
| CHEMBL4859103 | — | — | 1 | 7.37 |
| CHEMBL4862716 | — | — | 1 | 7.30 |
| CHEMBL4863615 | — | — | 1 | 7.19 |
| CHEMBL4854913 | — | — | 1 | 7.13 |
| CHEMBL4848527 | — | — | 1 | 7.12 |
| CHEMBL4872514 | — | — | 1 | 7.05 |
| CHEMBL140476 | HUPRINE Y | — | 1 | 6.74 |
| CHEMBL3304306 | — | — | 1 | 6.21 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.16 |
| CHEMBL164 | MYRICETIN | — | 1 | - |
| CHEMBL345124 | PROPIDIUM | — | 1 | - |
| CHEMBL3545559 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4866930 | — | IC50 | = | 31.9 | nM | 7.50 |
| CHEMBL4859103 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4862716 | — | IC50 | = | 50.3 | nM | 7.30 |
| CHEMBL4863615 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4854913 | — | IC50 | = | 74.8 | nM | 7.13 |
| CHEMBL4848527 | — | IC50 | = | 75.8 | nM | 7.12 |
| CHEMBL4872514 | — | IC50 | = | 88.5 | nM | 7.05 |
| CHEMBL140476 | HUPRINE Y | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL3304306 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 6980.0 | nM | 5.16 |
| CHEMBL164 | MYRICETIN | IC50 | - | — | - | |
| CHEMBL345124 | PROPIDIUM | IC50 | - | — | - | |
| CHEMBL3545559 | — | IC50 | - | — | - |