Assay Detail
Binding
CHEMBL4844304
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assay
32
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 8.40 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4867107 | — | — | 1 | 8.70 |
| CHEMBL4861383 | — | — | 1 | 8.64 |
| CHEMBL4865418 | — | — | 1 | 8.62 |
| CHEMBL4871231 | — | — | 1 | 8.62 |
| CHEMBL4875570 | — | — | 1 | 8.62 |
| CHEMBL4867211 | — | — | 1 | 8.60 |
| CHEMBL4875039 | — | — | 1 | 8.60 |
| CHEMBL4849097 | — | — | 1 | 8.59 |
| CHEMBL4874546 | — | — | 1 | 8.59 |
| CHEMBL4856035 | — | — | 1 | 8.59 |
| CHEMBL4862622 | — | — | 1 | 8.59 |
| CHEMBL4876612 | — | — | 1 | 8.54 |
| CHEMBL4853285 | — | — | 1 | 8.51 |
| CHEMBL4866800 | — | — | 1 | 8.49 |
| CHEMBL4861351 | — | — | 1 | 8.49 |
| CHEMBL4847705 | — | — | 1 | 8.49 |
| CHEMBL4865963 | — | — | 1 | 8.48 |
| CHEMBL4853973 | — | — | 1 | 8.44 |
| CHEMBL4857841 | — | — | 1 | 8.43 |
| CHEMBL4868683 | — | — | 1 | 8.43 |
| CHEMBL4871593 | — | — | 1 | 8.41 |
| CHEMBL1976040 | ADAVOSERTIB | 2.0 | 1 | 8.41 |
| CHEMBL4853185 | — | — | 2 | 8.37 |
| CHEMBL4861168 | — | — | 1 | 8.34 |
| CHEMBL4871803 | — | — | 1 | 8.32 |
| CHEMBL4879157 | — | — | 1 | 8.28 |
| CHEMBL4874090 | — | — | 1 | 8.19 |
| CHEMBL4856253 | — | — | 1 | 7.92 |
| CHEMBL4863657 | — | — | 1 | 7.66 |
| CHEMBL4847051 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4867107 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4861383 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4865418 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4871231 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4875570 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4867211 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4875039 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4849097 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4874546 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4862622 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4856035 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4876612 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4853285 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4847705 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4861351 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4866800 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4865963 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4853973 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL4857841 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4868683 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4871593 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL1976040 | ADAVOSERTIB | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4853185 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4861168 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4871803 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4879157 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL4853185 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4874090 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL4856253 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4863657 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4847051 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4877772 | — | IC50 | > | 100.0 | nM | - |