Assay Detail
Functional
CHEMBL4844396
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human LNCaP cells assessed as cell viability measured after 4 days in presence of R1881 by WST-8 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.57 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4877348 | — | — | 1 | 8.30 |
| CHEMBL4747369 | — | — | 1 | 8.00 |
| CHEMBL4861919 | — | — | 1 | 7.96 |
| CHEMBL4867584 | — | — | 1 | 7.89 |
| CHEMBL4879244 | — | — | 1 | 7.85 |
| CHEMBL4863542 | — | — | 1 | 7.09 |
| CHEMBL1082407 | ENZALUTAMIDE | 4.0 | 1 | 6.88 |
| CHEMBL4849514 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4877348 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4747369 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4861919 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4867584 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4879244 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4863542 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL1082407 | ENZALUTAMIDE | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL4849514 | — | IC50 | = | 237.0 | nM | 6.62 |