Assay Detail
Binding
CHEMBL4844527
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at 5-HT3 receptor in guinea-pig ileum assessed as inhibition of 5HT-induced contraction incubated for 15 mins
9
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT<sub>3</sub> and 5-HT<sub>6</sub> Receptor Antagonist with Antipsychotic and Procognitive Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pD2 | 7 | - | - |
| Kd | 2 | 7.11 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4849693 | — | — | 1 | 7.11 |
| CHEMBL46 | ONDANSETRON | 4.0 | 2 | 7.11 |
| CHEMBL4860809 | — | — | 1 | - |
| CHEMBL4867565 | — | — | 1 | - |
| CHEMBL4846153 | — | — | 1 | - |
| CHEMBL4862354 | — | — | 1 | - |
| CHEMBL4870374 | — | — | 1 | - |
| CHEMBL4863272 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4849693 | — | Kd | = | 77.62 | nM | 7.11 |
| CHEMBL46 | ONDANSETRON | Kd | = | 77.62 | nM | 7.11 |
| CHEMBL46 | ONDANSETRON | pD2 | = | 6.43 | — | - |
| CHEMBL4860809 | — | pD2 | = | 7.33 | — | - |
| CHEMBL4867565 | — | pD2 | = | 7.43 | — | - |
| CHEMBL4846153 | — | pD2 | = | 6.71 | — | - |
| CHEMBL4862354 | — | pD2 | = | 6.09 | — | - |
| CHEMBL4870374 | — | pD2 | = | 6.74 | — | - |
| CHEMBL4863272 | — | pD2 | = | 6.38 | — | - |