Assay Detail
Functional
CHEMBL4844615
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human LNCaP cells carrying AR T878A mutant assessed as cell viability by WST-8 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.65 | 7.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4862569 | — | — | 1 | 7.94 |
| CHEMBL4849497 | — | — | 1 | 7.94 |
| CHEMBL4849315 | — | — | 1 | 7.82 |
| CHEMBL4870803 | — | — | 1 | 7.79 |
| CHEMBL4872965 | — | — | 1 | 7.66 |
| CHEMBL4854467 | — | — | 1 | 7.65 |
| CHEMBL4862963 | BAVDEGALUTAMIDE | 1.0 | 1 | 7.48 |
| CHEMBL1082407 | ENZALUTAMIDE | 4.0 | 1 | 6.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4862569 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL4849497 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL4849315 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL4870803 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL4872965 | — | IC50 | = | 21.7 | nM | 7.66 |
| CHEMBL4854467 | — | IC50 | = | 22.3 | nM | 7.65 |
| CHEMBL4862963 | BAVDEGALUTAMIDE | IC50 | = | 33.1 | nM | 7.48 |
| CHEMBL1082407 | ENZALUTAMIDE | IC50 | = | 133.0 | nM | 6.88 |