Assay Detail
Functional
CHEMBL4844710
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Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.18 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4870989 | — | — | 1 | 6.82 |
| CHEMBL4866635 | — | — | 1 | 6.80 |
| CHEMBL4854663 | — | — | 1 | 6.70 |
| CHEMBL4869036 | — | — | 1 | 6.68 |
| CHEMBL4847191 | — | — | 1 | 6.55 |
| CHEMBL4858593 | — | — | 1 | 6.52 |
| CHEMBL4875408 | — | — | 1 | 6.48 |
| CHEMBL4857061 | — | — | 1 | 6.46 |
| CHEMBL4847405 | — | — | 1 | 6.43 |
| CHEMBL4868840 | — | — | 1 | 6.40 |
| CHEMBL4870663 | — | — | 1 | 6.39 |
| CHEMBL4866818 | — | — | 1 | 6.37 |
| CHEMBL4864795 | — | — | 1 | 6.37 |
| CHEMBL4851930 | — | — | 1 | 6.25 |
| CHEMBL1499544 | — | — | 1 | 6.18 |
| CHEMBL4852206 | — | — | 1 | 6.16 |
| CHEMBL4870519 | — | — | 1 | 6.13 |
| CHEMBL4857735 | — | — | 1 | 6.12 |
| CHEMBL4876863 | — | — | 1 | 6.05 |
| CHEMBL4848813 | — | — | 1 | 6.03 |
| CHEMBL4857142 | — | — | 1 | 5.96 |
| CHEMBL4747331 | — | — | 1 | 5.92 |
| CHEMBL4858099 | — | — | 1 | 5.68 |
| CHEMBL4850327 | — | — | 1 | 5.64 |
| CHEMBL4854607 | — | — | 1 | 5.52 |
| CHEMBL4877321 | — | — | 1 | 5.50 |
| CHEMBL4846939 | — | — | 1 | 4.80 |
| CHEMBL4848626 | — | — | 1 | - |
| CHEMBL4846227 | — | — | 1 | - |
| CHEMBL4858640 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4870989 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4866635 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4854663 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4869036 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4847191 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4858593 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4875408 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4857061 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4847405 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4868840 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4870663 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4866818 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4864795 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4851930 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL1499544 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4852206 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4870519 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4857735 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4876863 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4848813 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL4857142 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4747331 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4858099 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4850327 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4854607 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4877321 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4846939 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4848626 | — | IC50 | - | — | - | |
| CHEMBL4846227 | — | IC50 | - | — | - | |
| CHEMBL4858640 | — | IC50 | - | — | - |