Assay Detail
Functional
CHEMBL4844711
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Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 48 hrs in presence of Fer-1 by MTT assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.36 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4868840 | — | — | 1 | 5.89 |
| CHEMBL4858099 | — | — | 1 | 5.60 |
| CHEMBL4876863 | — | — | 1 | 5.49 |
| CHEMBL4869036 | — | — | 1 | 5.46 |
| CHEMBL4848813 | — | — | 1 | 5.46 |
| CHEMBL4747331 | — | — | 1 | 5.43 |
| CHEMBL4866635 | — | — | 1 | 5.41 |
| CHEMBL4854663 | — | — | 1 | 5.41 |
| CHEMBL4875408 | — | — | 1 | 5.38 |
| CHEMBL4864795 | — | — | 1 | 5.38 |
| CHEMBL4857735 | — | — | 1 | 5.38 |
| CHEMBL4866818 | — | — | 1 | 5.37 |
| CHEMBL4852206 | — | — | 1 | 5.37 |
| CHEMBL4850327 | — | — | 1 | 5.36 |
| CHEMBL4858593 | — | — | 1 | 5.35 |
| CHEMBL4847405 | — | — | 1 | 5.35 |
| CHEMBL4870519 | — | — | 1 | 5.34 |
| CHEMBL4857061 | — | — | 1 | 5.34 |
| CHEMBL4847191 | — | — | 1 | 5.33 |
| CHEMBL4870989 | — | — | 1 | 5.33 |
| CHEMBL4870663 | — | — | 1 | 5.31 |
| CHEMBL4854607 | — | — | 1 | 5.31 |
| CHEMBL4851930 | — | — | 1 | 5.30 |
| CHEMBL4877321 | — | — | 1 | 5.28 |
| CHEMBL4857142 | — | — | 1 | 5.19 |
| CHEMBL1499544 | — | — | 1 | 5.14 |
| CHEMBL4846939 | — | — | 1 | 4.80 |
| CHEMBL4848626 | — | — | 1 | - |
| CHEMBL4846227 | — | — | 1 | - |
| CHEMBL4858640 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4868840 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4858099 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4876863 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL4869036 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4848813 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL4747331 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4866635 | — | IC50 | = | 3920.0 | nM | 5.41 |
| CHEMBL4854663 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4875408 | — | IC50 | = | 4210.0 | nM | 5.38 |
| CHEMBL4864795 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4857735 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4866818 | — | IC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL4852206 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4850327 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4858593 | — | IC50 | = | 4430.0 | nM | 5.35 |
| CHEMBL4847405 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4870519 | — | IC50 | = | 4570.0 | nM | 5.34 |
| CHEMBL4857061 | — | IC50 | = | 4520.0 | nM | 5.34 |
| CHEMBL4847191 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4870989 | — | IC50 | = | 4730.0 | nM | 5.33 |
| CHEMBL4870663 | — | IC50 | = | 4880.0 | nM | 5.31 |
| CHEMBL4854607 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4851930 | — | IC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL4877321 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4857142 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL1499544 | — | IC50 | = | 7310.0 | nM | 5.14 |
| CHEMBL4846939 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4848626 | — | IC50 | - | — | - | |
| CHEMBL4846227 | — | IC50 | - | — | - | |
| CHEMBL4858640 | — | IC50 | - | — | - |