Assay Detail
Functional
CHEMBL4844744
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel hybrids targeting mTOR and HDACs for potential treatment of hepatocellular carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.31 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545097 | SAPANISERTIB | 2.0 | 1 | 8.15 |
| CHEMBL4874936 | — | — | 1 | 5.83 |
| CHEMBL4870348 | — | — | 1 | 5.56 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.41 |
| CHEMBL4846560 | — | — | 1 | 5.24 |
| CHEMBL4846776 | — | — | 1 | 5.13 |
| CHEMBL4863909 | — | — | 1 | 5.04 |
| CHEMBL4851752 | — | — | 1 | 5.00 |
| CHEMBL4876402 | — | — | 1 | 5.00 |
| CHEMBL4858329 | — | — | 1 | 4.63 |
| CHEMBL4877972 | — | — | 1 | 4.38 |
| CHEMBL4847792 | — | — | 1 | 4.29 |
| CHEMBL4858719 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545097 | SAPANISERTIB | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4874936 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL4870348 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL4846560 | — | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL4846776 | — | IC50 | = | 7380.0 | nM | 5.13 |
| CHEMBL4863909 | — | IC50 | = | 9220.0 | nM | 5.04 |
| CHEMBL4851752 | — | IC50 | = | 9910.0 | nM | 5.00 |
| CHEMBL4876402 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL4858329 | — | IC50 | = | 23480.0 | nM | 4.63 |
| CHEMBL4877972 | — | IC50 | = | 41230.0 | nM | 4.38 |
| CHEMBL4847792 | — | IC50 | = | 50860.0 | nM | 4.29 |
| CHEMBL4858719 | — | IC50 | > | 100000.0 | nM | - |