Assay Detail
Binding
CHEMBL4845577
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PIM2 (unknown origin) using ARKRRRHPSGPPTA as peptide substrate by ADP Hunter Plus assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-2 (CHEMBL4523) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.99 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4878958 | — | — | 1 | 8.10 |
| CHEMBL4860369 | — | — | 1 | 7.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4878958 | — | IC50 | = | 8.04 | nM | 8.10 |
| CHEMBL4860369 | — | IC50 | = | 13.3 | nM | 7.88 |