Assay Detail
Binding
CHEMBL4880071
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Fluorometric imaging plate reader (FLIPR)-based Ca2+ assay
2
Total Activities
2
Compounds Tested
1
Activity Types
5
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily A member 1 (CHEMBL6007) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Data for DCP probe A-079
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.17 | 7.17 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Additional information | Additional information | - | — | AITC (allylthiocyanate) evoked robust increase of intracellular Ca2+ was blocked. |
| Assay publication | Assay publication | - | — | PMID: 21402443 |
| Compound concentration | Compound concentration | - | — | 0.03-0.3 |
| Target protein length | Target protein length | - | — | full length |
| Target protein type | Target protein type | - | — | recombinant protein expressed in cells |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3697701 | A-079 | — | 1 | 7.17 |
| CHEMBL3701197 | A-226 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3697701 | A-079 | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL3701197 | A-226 | IC50 | > | 100000.0 | nM | - |