Assay Detail
Binding
CHEMBL4880319
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cellular FLIPR (fluorometric imaging plate reader) assay
2
Total Activities
2
Compounds Tested
2
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Data for DCP probe ABT-724
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 7.91 | 7.91 |
| IC50 | 1 | - | - |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Assay publication | Assay publication | - | — | PMID: 15239663 |
| Target protein type | Target protein type | - | — | HEX293 cells stably expressing cloned human DRD4.4 and G protein chimera Gαqo5 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440687 | ABT-724 | — | 1 | 7.91 |
| CHEMBL4630641 | A-769 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440687 | ABT-724 | EC50 | = | 12.4 | nM | 7.91 |
| CHEMBL4630641 | A-769 | IC50 | > | 10000.0 | nM | - |