Assay Detail
Binding
CHEMBL4880478
Review assay metadata, readout intent, target linkage, and publication context from the same page.
HBE-TECC (Human Bronchial Epithelial- Trans-Epithelial Current Clamp) assay
2
Total Activities
2
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Cystic fibrosis transmembrane conductance regulator (CHEMBL4051) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Data for DCP probe A-1596586
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.55 | 7.55 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Assay publication | Assay publication | - | — | PMID: 29251932 |
| Target protein type | Target protein type | - | — | primary human bronchial epithelial (HBE) cells from F508del CF patients |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4093612 | A-1596586 | — | 1 | 7.55 |
| CHEMBL4066040 | A-1596584 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4093612 | A-1596586 | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4066040 | A-1596584 | EC50 | > | 3000.0 | nM | - |