Assay Detail

CHEMBL4882309

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Binding

Rat platelet swelling inhibition (rPSA) assay

ChEMBL ↗

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Target

Sodium/hydrogen exchanger 1 (CHEMBL2577) ↗

Open DB target context

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Sodium/hydrogen exchanger 1 (CHEMBL2577) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Sodium/hydrogen exchanger 1

CHEMBL2577

Anchored from Assay target.

Protein identity Sodium/hydrogen exchanger 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Sodium/hydrogen exchanger 1 (CHEMBL2577) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Data for DCP probe BI-9627

SGC Frankfurt
(2021)
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.86	6.86

Assay Parameters

Parameter	Type	Value	Units	Text
Assay publication	Assay publication	-	—	PMID: 22803959

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2170610	BI 9627	—	1	6.86

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2170610	BI 9627	IC50	=	138.0	nM	6.86