Assay Detail

CHEMBL4882584

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Binding

Human SKY enzyme assay

ChEMBL ↗

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Target

Tyrosine-protein kinase SYK (CHEMBL2599) ↗

Open DB target context

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Tyrosine-protein kinase SYK (CHEMBL2599) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Tyrosine-protein kinase SYK

CHEMBL2599

Anchored from Assay target.

Protein identity Tyrosine-protein kinase SYK

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Tyrosine-protein kinase SYK (CHEMBL2599) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Data for DCP probe MRL-SYKi

SGC Frankfurt
(2021)
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.19	9.05

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3685796	MRL-SYKi	—	1	9.05
CHEMBL4530401	MRL-SYKi-NC	—	1	5.33

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3685796	MRL-SYKi	IC50	=	0.9	nM	9.05
CHEMBL4530401	MRL-SYKi-NC	IC50	=	4700.0	nM	5.33