Assay Detail
Functional
CHEMBL4882633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
cAMP Functional Assay
2
Total Activities
2
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Data for DCP probe CRTH2 antagonist, MK-7246
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.52 | 8.52 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Assay publication | Assay publication | - | — | PMID: 12466225 |
| Target protein type | Target protein type | - | — | HEK-hCRTH2 cells |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL561132 | MK-7246 | 1.0 | 1 | 8.52 |
| CHEMBL1643772 | CRTH2-negative-control | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL561132 | MK-7246 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1643772 | CRTH2-negative-control | IC50 | > | 10000.0 | nM | - |