Assay Detail

CHEMBL4882635

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Binding

Functional Assay: Eosinophil CD11b (whole blood)

ChEMBL ↗

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Target

Prostaglandin D2 receptor 2 (CHEMBL5071) ↗

Open DB target context

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Prostaglandin D2 receptor 2 (CHEMBL5071) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Prostaglandin D2 receptor 2

CHEMBL5071

Anchored from Assay target.

Protein identity Prostaglandin D2 receptor 2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Tissue	Blood
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Prostaglandin D2 receptor 2 (CHEMBL5071) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Data for DCP probe CRTH2 antagonist, MK-7246

SGC Frankfurt
(2021)
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.64	8.64

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL561132	MK-7246	1.0	1	8.64

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL561132	MK-7246	IC50	=	2.3	nM	8.64