Assay Detail
Binding
CHEMBL4882637
Review assay metadata, readout intent, target linkage, and publication context from the same page.
LRRK2 Biochemical Assay
2
Total Activities
2
Compounds Tested
1
Activity Types
3
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Leucine-rich repeat serine/threonine-protein kinase 2 (CHEMBL1075104) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Data for DCP probe MLi-2
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.97 | 8.74 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Additional information | Additional information | - | — | LanthaScreen |
| Assay publication | Assay publication | - | — | PMID: 26407721 |
| Target protein type | Target protein type | - | — | GST-tagged truncated human mutant G2019S LRRK2 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4098877 | MLi-2 | — | 1 | 8.74 |
| CHEMBL4560589 | MLi-2-NC | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4098877 | MLi-2 | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4560589 | MLi-2-NC | IC50 | = | 6480.0 | nM | 5.19 |