Assay Detail

CHEMBL4883792

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Binding

TNF-α release ( LPS stim., WB)

ChEMBL ↗

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Target

Tumor necrosis factor (CHEMBL1825) ↗

Open DB target context

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Primary target Tumor necrosis factor

CHEMBL1825

Anchored from Assay target.

Protein identity Tumor necrosis factor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Tumor necrosis factor (CHEMBL1825) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Data for DCP probe FS-694

SGC Frankfurt
(2021)
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.99	7.42

Assay Parameters

Parameter	Type	Value	Units	Text
Assay publication	Assay publication	-	—	PMID: 28834431

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2316207	FS-694	—	1	7.42
CHEMBL4436748	SR-318	—	1	6.55

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2316207	FS-694	IC50	=	38.0	nM	7.42
CHEMBL4436748	SR-318	IC50	=	283.0	nM	6.55