Assay Detail
Binding
CHEMBL4885737
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TR-FRET assay (BRD4 BD2)
3
Total Activities
3
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Data for DCP probe GSK046
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.54 | 7.31 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Assay publication | Assay publication | - | — | PMID: 32193360 |
| Target protein length | Target protein length | - | — | BD2 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4636881 | GSK046 | — | 1 | 7.31 |
| CHEMBL4635134 | GSK620 | — | 1 | 7.09 |
| CHEMBL4639128 | GSK778 | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4636881 | GSK046 | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4635134 | GSK620 | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4639128 | GSK778 | IC50 | = | 5843.0 | nM | 5.23 |