Assay Detail

CHEMBL4886922

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Binding

Inhibition of binding to PTGER2

ChEMBL ↗

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Target

Prostaglandin E2 receptor EP2 subtype (CHEMBL1881) ↗

Open DB target context

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Prostaglandin E2 receptor EP2 subtype (CHEMBL1881) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Prostaglandin E2 receptor EP2 subtype

CHEMBL1881

Anchored from Assay target.

Protein identity Prostaglandin E2 receptor EP2 subtype

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Prostaglandin E2 receptor EP2 subtype (CHEMBL1881) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Data for DCP probe PF-04418948

SGC Frankfurt
(2021)
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.10	8.30

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3286797	PF-04418948	1.0	1	8.30
CHEMBL4552554	PF-04475866	—	1	5.89

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3286797	PF-04418948	IC50	=	5.0	nM	8.30
CHEMBL4552554	PF-04475866	IC50	=	1300.0	nM	5.89