Compound Detail
CHEMBL4552554
PF-04475866 Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL4552554 |
| Name | PF-04475866 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KBYIQQODUSXDFL-UHFFFAOYSA-N |
3
Targets
6
Activities
2
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
408.2
MW (Da)
3.19
ALogP
3
HBA
1
HBD
66.8
PSA (Ų)
0.83
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 5.0
IC50 2 meas. best 5.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP2 subtype CHEMBL1881 | IC50 | 5.89 | 5.89 | 1300.0 | 2 |
| D(1A) dopamine receptor CHEMBL2056 | Ki | 5.0 | 5.0 | 10000.0 | 2 |
| Histamine H4 receptor CHEMBL3759 | Ki | 5.0 | 5.0 | 10000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP2 subtype | IC50 | = | 1300.0 | nM | 5.89 | Inhibition of binding to PTGER2 | - |
| Prostaglandin E2 receptor EP2 subtype | IC50 | = | 1300.0 | nM | 5.89 | Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000342a PTGER2 | - |
| Histamine H4 receptor | Ki | = | 10000.0 | nM | 5.0 | GPCRScan assay: inhibition of H4 | - |
| Histamine H4 receptor | Ki | = | 10000.0 | nM | 5.0 | GPCRScan assay: inhibition of H4 | - |
| D(1A) dopamine receptor | Ki | = | 10000.0 | nM | 5.0 | GPCRScan assay: inhibition of D1 | - |
| D(1A) dopamine receptor | Ki | = | 10000.0 | nM | 5.0 | GPCRScan assay: inhibition of D1 | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL5674860 | Colon cancer organoid | 12 |
| - | 10.6019/CHEMBL5724558 | Colon cancer organoid | 12 |
| - | 10.6019/CHEMBL4689842 | HEK-293T | 10 |
| - | 10.6019/CHEMBL4689842 | U2OS | 8 |
| - | 10.6019/CHEMBL5608141 | Colon cancer organoid | 6 |
| - | 10.6019/CHEMBL4689842 | Fibroblast | 5 |
| - | 10.1158/2159-8290.CD-23-0050 | Colon cancer organoid | 5 |
| - | 10.6019/CHEMBL4507298 | Histamine H4 receptor | 3 |
| - | 10.6019/CHEMBL4507298 | D(1A) dopamine receptor | 3 |
| - | 10.6019/CHEMBL4507298 | GABA-A receptor; anion channel | 2 |
| - | 10.6019/CHEMBL4507298 | 5-hydroxytryptamine receptor 1D | 1 |
| - | 10.6019/CHEMBL4507298 | 5-hydroxytryptamine receptor 6 | 1 |
| - | 10.6019/CHEMBL4507298 | 5-hydroxytryptamine receptor 7 | 1 |
| - | 10.6019/CHEMBL4507298 | Beta-2 adrenergic receptor | 1 |
| - | 10.6019/CHEMBL4507298 | D(2) dopamine receptor | 1 |
| - | 10.6019/CHEMBL4507298 | Delta-type opioid receptor | 1 |
| - | 10.6019/CHEMBL4507298 | 5-hydroxytryptamine receptor 1B | 1 |
| - | 10.6019/CHEMBL4507298 | Beta-1 adrenergic receptor | 1 |
| - | 10.6019/CHEMBL4507298 | Muscarinic acetylcholine receptor M5 | 1 |
| - | 10.6019/CHEMBL4507298 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine