Assay Detail
Functional
CHEMBL4888488
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Hit confirmation in dose-response curve in NF54 nanoGlo assay, at 72h
649
Total Activities
647
Compounds Tested
1
Activity Types
1
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Erythrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum ,using a nano luciferase reporter read-out
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 649 | 5.77 | 8.72 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| TIMEPOINT | TIMEPOINT | 72.0 | hour | — |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4987660 | — | — | 1 | 8.72 |
| CHEMBL5005658 | — | — | 1 | 8.71 |
| CHEMBL4995739 | — | — | 1 | 8.69 |
| CHEMBL4923208 | — | — | 1 | 8.56 |
| CHEMBL4958975 | — | — | 1 | 8.23 |
| CHEMBL4971082 | — | — | 1 | 8.23 |
| CHEMBL4928393 | — | — | 1 | 8.21 |
| CHEMBL4892343 | — | — | 1 | 8.08 |
| CHEMBL4936594 | — | — | 1 | 7.75 |
| CHEMBL1532367 | — | — | 1 | 7.57 |
| CHEMBL5311065 | — | — | 1 | 7.38 |
| CHEMBL5005705 | — | — | 1 | 7.32 |
| CHEMBL4948220 | — | — | 1 | 7.06 |
| CHEMBL4948482 | — | — | 1 | 7.00 |
| CHEMBL4987022 | — | — | 1 | 6.84 |
| CHEMBL4925204 | — | — | 1 | 6.80 |
| CHEMBL5312609 | — | — | 1 | 6.79 |
| CHEMBL4979552 | — | — | 1 | 6.71 |
| CHEMBL5011155 | — | — | 1 | 6.68 |
| CHEMBL4898311 | — | — | 1 | 6.64 |
| CHEMBL4961462 | — | — | 1 | 6.60 |
| CHEMBL4958842 | — | — | 1 | 6.59 |
| CHEMBL1619097 | — | — | 1 | 6.58 |
| CHEMBL4988153 | — | — | 1 | 6.58 |
| CHEMBL5313438 | — | — | 1 | 6.58 |
| CHEMBL4890710 | — | — | 1 | 6.56 |
| CHEMBL4934170 | — | — | 1 | 6.54 |
| CHEMBL4976730 | — | — | 1 | 6.52 |
| CHEMBL4986437 | — | — | 1 | 6.51 |
| CHEMBL4982236 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4987660 | — | IC50 | = | 1.91 | nM | 8.72 |
| CHEMBL5005658 | — | IC50 | = | 1.95 | nM | 8.71 |
| CHEMBL4995739 | — | IC50 | = | 2.04 | nM | 8.69 |
| CHEMBL4923208 | — | IC50 | = | 2.75 | nM | 8.56 |
| CHEMBL4971082 | — | IC50 | = | 5.89 | nM | 8.23 |
| CHEMBL4958975 | — | IC50 | = | 5.89 | nM | 8.23 |
| CHEMBL4928393 | — | IC50 | = | 6.17 | nM | 8.21 |
| CHEMBL4892343 | — | IC50 | = | 8.32 | nM | 8.08 |
| CHEMBL4936594 | — | IC50 | = | 17.8 | nM | 7.75 |
| CHEMBL1532367 | — | IC50 | = | 26.9 | nM | 7.57 |
| CHEMBL5311065 | — | IC50 | = | 41.7 | nM | 7.38 |
| CHEMBL5005705 | — | IC50 | = | 47.9 | nM | 7.32 |
| CHEMBL4948220 | — | IC50 | = | 87.1 | nM | 7.06 |
| CHEMBL4948482 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4987022 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL4925204 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL5312609 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL4979552 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL5011155 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL4898311 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL4961462 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL4958842 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL4988153 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL5313438 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL1619097 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL4890710 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL4934170 | — | IC50 | = | 288.4 | nM | 6.54 |
| CHEMBL4976730 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL4982236 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL4986437 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL4899222 | — | IC50 | = | 316.2 | nM | 6.50 |
| CHEMBL4934507 | — | IC50 | = | 323.6 | nM | 6.49 |
| CHEMBL5310812 | — | IC50 | = | 324.0 | nM | 6.49 |
| CHEMBL4898267 | — | IC50 | = | 331.1 | nM | 6.48 |
| CHEMBL4962731 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL4940671 | — | IC50 | = | 407.4 | nM | 6.39 |
| CHEMBL4999643 | — | IC50 | = | 457.1 | nM | 6.34 |
| CHEMBL4915187 | — | IC50 | = | 457.0 | nM | 6.34 |
| CHEMBL4979636 | — | IC50 | = | 468.0 | nM | 6.33 |
| CHEMBL5020386 | — | IC50 | = | 478.6 | nM | 6.32 |
| CHEMBL4909561 | — | IC50 | = | 479.0 | nM | 6.32 |
| CHEMBL4923809 | — | IC50 | = | 478.6 | nM | 6.32 |
| CHEMBL4927183 | — | IC50 | = | 489.8 | nM | 6.31 |
| CHEMBL5019621 | — | IC50 | = | 489.8 | nM | 6.31 |
| CHEMBL4902391 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4888548 | — | IC50 | = | 501.0 | nM | 6.30 |
| CHEMBL5002197 | — | IC50 | = | 501.2 | nM | 6.30 |
| CHEMBL4981903 | — | IC50 | = | 501.2 | nM | 6.30 |
| CHEMBL5309833 | — | IC50 | = | 513.0 | nM | 6.29 |
| CHEMBL4920363 | — | IC50 | = | 512.9 | nM | 6.29 |