Compound Detail
CHEMBL5310812
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5310812 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JDYDVHFYEHVRPL-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
284.8
MW (Da)
4.15
ALogP
3
HBA
2
HBD
59.1
PSA (Ų)
0.71
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 6.52 | 6.4767 | 302.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 302.0 | nM | 6.52 | Hit confirmation in dose-response curve in Dd2 pLDH assay, at 72h | 38116432 |
| Plasmodium falciparum | IC50 | = | 324.0 | nM | 6.49 | Hit confirmation in dose-response curve in NF54 nanoGlo assay, at 72h | 38116432 |
| Plasmodium falciparum | IC50 | = | 380.0 | nM | 6.42 | Hit confirmation in dose-response curve in NF54 pLDH assay, at 72h | 38116432 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38116432 | 10.1021/acsmedchemlett.3c00369 | Plasmodium falciparum | 8 |
| 38116432 | 10.1021/acsmedchemlett.3c00369 | HepG2 | 1 |
Data from ChEMBL 36 via Core Engine