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Assay Detail

CHEMBL4888490

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Functional
Hit confirmation in dose-response curve in Dd2 pLDH assay, at 72h
ChEMBL ↗
649
Total Activities
647
Compounds Tested
1
Activity Types
1
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Cell Type Erythrocyte
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗
Type ORGANISM
Organism Plasmodium falciparum

Publication

Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum ,using a nano luciferase reporter read-out
Dechering K; Duffey M
(2022)
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 649 5.61 7.37

Assay Parameters

Parameter Type Value Units Text
TIMEPOINT TIMEPOINT 72.0 hour —

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5311065 — — 1 7.37
CHEMBL4948220 — — 1 7.06
CHEMBL4948482 — — 1 7.00
CHEMBL4987022 — — 1 6.88
CHEMBL5312609 — — 1 6.87
CHEMBL4958842 — — 1 6.63
CHEMBL4981903 — — 1 6.57
CHEMBL4979552 — — 1 6.57
CHEMBL5313438 — — 1 6.57
CHEMBL4898311 — — 1 6.56
CHEMBL5310812 — — 1 6.52
CHEMBL5020386 — — 1 6.45
CHEMBL1619097 — — 1 6.43
CHEMBL4899222 — — 1 6.43
CHEMBL4909561 — — 1 6.40
CHEMBL4955825 — — 1 6.39
CHEMBL4951537 — — 1 6.38
CHEMBL4962438 — — 1 6.38
CHEMBL5308851 — — 1 6.38
CHEMBL4940671 — — 1 6.36
CHEMBL5011155 — — 1 6.36
CHEMBL5313405 — — 1 6.36
CHEMBL4984823 — — 1 6.35
CHEMBL4967714 — — 1 6.30
CHEMBL4913908 — — 1 6.28
CHEMBL5314151 — — 1 6.28
CHEMBL4962731 — — 1 6.27
CHEMBL5310841 — — 1 6.24
CHEMBL4980566 — — 1 6.23
CHEMBL5018385 — — 1 6.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5311065 — IC50 = 43.0 nM 7.37
CHEMBL4948220 — IC50 = 87.1 nM 7.06
CHEMBL4948482 — IC50 = 100.0 nM 7.00
CHEMBL4987022 — IC50 = 132.0 nM 6.88
CHEMBL5312609 — IC50 = 135.0 nM 6.87
CHEMBL4958842 — IC50 = 234.0 nM 6.63
CHEMBL4979552 — IC50 = 269.0 nM 6.57
CHEMBL4981903 — IC50 = 269.0 nM 6.57
CHEMBL5313438 — IC50 = 269.0 nM 6.57
CHEMBL4898311 — IC50 = 275.0 nM 6.56
CHEMBL5310812 — IC50 = 302.0 nM 6.52
CHEMBL5020386 — IC50 = 355.0 nM 6.45
CHEMBL4899222 — IC50 = 372.0 nM 6.43
CHEMBL1619097 — IC50 = 372.0 nM 6.43
CHEMBL4909561 — IC50 = 398.0 nM 6.40
CHEMBL4955825 — IC50 = 407.0 nM 6.39
CHEMBL4951537 — IC50 = 417.0 nM 6.38
CHEMBL5308851 — IC50 = 417.0 nM 6.38
CHEMBL4962438 — IC50 = 417.0 nM 6.38
CHEMBL5313405 — IC50 = 437.0 nM 6.36
CHEMBL5011155 — IC50 = 437.0 nM 6.36
CHEMBL4940671 — IC50 = 437.0 nM 6.36
CHEMBL4984823 — IC50 = 447.0 nM 6.35
CHEMBL4967714 — IC50 = 501.0 nM 6.30
CHEMBL4913908 — IC50 = 525.0 nM 6.28
CHEMBL5314151 — IC50 = 525.0 nM 6.28
CHEMBL4962731 — IC50 = 537.0 nM 6.27
CHEMBL5310841 — IC50 = 575.0 nM 6.24
CHEMBL4980566 — IC50 = 589.0 nM 6.23
CHEMBL5018385 — IC50 = 603.0 nM 6.22
CHEMBL4890710 — IC50 = 602.0 nM 6.22
CHEMBL4934507 — IC50 = 631.0 nM 6.20
CHEMBL1625978 — IC50 = 646.0 nM 6.19
CHEMBL4924092 — IC50 = 646.0 nM 6.19
CHEMBL4967973 — IC50 = 661.0 nM 6.18
CHEMBL4996121 — IC50 = 661.0 nM 6.18
CHEMBL1621810 — IC50 = 661.0 nM 6.18
CHEMBL5309024 — IC50 = 692.0 nM 6.16
CHEMBL5314195 — IC50 = 708.0 nM 6.15
CHEMBL5019322 — IC50 = 708.0 nM 6.15
CHEMBL4911569 — IC50 = 708.0 nM 6.15
CHEMBL5002197 — IC50 = 724.0 nM 6.14
CHEMBL4915187 — IC50 = 741.0 nM 6.13
CHEMBL5313193 — IC50 = 741.0 nM 6.13
CHEMBL5310718 — IC50 = 741.0 nM 6.13
CHEMBL4898267 — IC50 = 759.0 nM 6.12
CHEMBL1616375 — IC50 = 776.0 nM 6.11
CHEMBL4974547 — IC50 = 794.0 nM 6.10
CHEMBL4928484 — IC50 = 832.0 nM 6.08
CHEMBL534103 — IC50 = 871.0 nM 6.06