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Assay Detail

CHEMBL4888489

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Functional
Hit confirmation in dose-response curve in NF54 pLDH assay, at 72h
ChEMBL ↗
649
Total Activities
647
Compounds Tested
1
Activity Types
1
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Cell Type Erythrocyte
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗
Type ORGANISM
Organism Plasmodium falciparum

Publication

Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum ,using a nano luciferase reporter read-out
Dechering K; Duffey M
(2022)
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 649 5.60 8.78

Assay Parameters

Parameter Type Value Units Text
TIMEPOINT TIMEPOINT 72.0 hour —

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4987660 — — 1 8.78
CHEMBL5005658 — — 1 8.67
CHEMBL4995739 — — 1 8.48
CHEMBL4923208 — — 1 8.46
CHEMBL4971082 — — 1 8.00
CHEMBL4928393 — — 1 7.98
CHEMBL4958975 — — 1 7.95
CHEMBL4892343 — — 1 7.90
CHEMBL4924953 — — 1 7.74
CHEMBL4936594 — — 1 7.65
CHEMBL5311065 — — 1 7.51
CHEMBL1532367 — — 1 7.15
CHEMBL5005705 — — 1 7.08
CHEMBL4927183 — — 1 7.06
CHEMBL4928484 — — 1 7.05
CHEMBL5018284 — — 1 7.00
CHEMBL4948482 — — 1 6.82
CHEMBL4948220 — — 1 6.78
CHEMBL5312609 — — 1 6.78
CHEMBL4987022 — — 1 6.76
CHEMBL4962438 — — 1 6.74
CHEMBL5019621 — — 1 6.58
CHEMBL4981903 — — 1 6.57
CHEMBL4982236 — — 1 6.55
CHEMBL4979552 — — 1 6.51
CHEMBL4958842 — — 1 6.48
CHEMBL4969023 — — 1 6.46
CHEMBL4899222 — — 1 6.44
CHEMBL5020386 — — 1 6.42
CHEMBL4955825 — — 1 6.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4987660 — IC50 = 1.66 nM 8.78
CHEMBL5005658 — IC50 = 2.14 nM 8.67
CHEMBL4995739 — IC50 = 3.31 nM 8.48
CHEMBL4923208 — IC50 = 3.47 nM 8.46
CHEMBL4971082 — IC50 = 10.0 nM 8.00
CHEMBL4928393 — IC50 = 10.5 nM 7.98
CHEMBL4958975 — IC50 = 11.2 nM 7.95
CHEMBL4892343 — IC50 = 12.6 nM 7.90
CHEMBL4924953 — IC50 = 18.2 nM 7.74
CHEMBL4936594 — IC50 = 22.4 nM 7.65
CHEMBL5311065 — IC50 = 30.9 nM 7.51
CHEMBL1532367 — IC50 = 70.8 nM 7.15
CHEMBL5005705 — IC50 = 83.2 nM 7.08
CHEMBL4927183 — IC50 = 87.1 nM 7.06
CHEMBL4928484 — IC50 = 89.1 nM 7.05
CHEMBL5018284 — IC50 = 100.0 nM 7.00
CHEMBL4948482 — IC50 = 151.0 nM 6.82
CHEMBL5312609 — IC50 = 166.0 nM 6.78
CHEMBL4948220 — IC50 = 166.0 nM 6.78
CHEMBL4987022 — IC50 = 174.0 nM 6.76
CHEMBL4962438 — IC50 = 182.0 nM 6.74
CHEMBL5019621 — IC50 = 263.0 nM 6.58
CHEMBL4981903 — IC50 = 269.0 nM 6.57
CHEMBL4982236 — IC50 = 282.0 nM 6.55
CHEMBL4979552 — IC50 = 309.0 nM 6.51
CHEMBL4958842 — IC50 = 331.0 nM 6.48
CHEMBL4969023 — IC50 = 347.0 nM 6.46
CHEMBL4899222 — IC50 = 363.0 nM 6.44
CHEMBL5020386 — IC50 = 380.0 nM 6.42
CHEMBL4955825 — IC50 = 380.0 nM 6.42
CHEMBL5310812 — IC50 = 380.0 nM 6.42
CHEMBL5313438 — IC50 = 389.0 nM 6.41
CHEMBL4909561 — IC50 = 389.0 nM 6.41
CHEMBL5310841 — IC50 = 398.0 nM 6.40
CHEMBL5313405 — IC50 = 437.0 nM 6.36
CHEMBL4967714 — IC50 = 447.0 nM 6.35
CHEMBL4980720 — IC50 = 447.0 nM 6.35
CHEMBL1619097 — IC50 = 513.0 nM 6.29
CHEMBL4888713 — IC50 = 513.0 nM 6.29
CHEMBL5314151 — IC50 = 562.0 nM 6.25
CHEMBL4984823 — IC50 = 562.0 nM 6.25
CHEMBL5001025 — IC50 = 562.0 nM 6.25
CHEMBL5011155 — IC50 = 575.0 nM 6.24
CHEMBL5308851 — IC50 = 589.0 nM 6.23
CHEMBL4913908 — IC50 = 603.0 nM 6.22
CHEMBL5002197 — IC50 = 617.0 nM 6.21
CHEMBL4940671 — IC50 = 676.0 nM 6.17
CHEMBL4898311 — IC50 = 676.0 nM 6.17
CHEMBL5313620 — IC50 = 724.0 nM 6.14
CHEMBL1621810 — IC50 = 741.0 nM 6.13