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Assay Detail

CHEMBL5029258

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of jack bean alpha-mannosidase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Canavalia ensiformis
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Alpha-mannosidase (CHEMBL3392945)
Type SINGLE PROTEIN
Organism Canavalia ensiformis

Publication

Positional Isomeric Effects on the Optical Properties, Multivalent Glycosidase Inhibition Effect, and Hypoglycemic Effect of Perylene Bisimide-deoxynojirimycin Conjugates.
Li RF, Yang JX, Liu J, Ai GM, Zhang HY, Xu LY, Chen SB, Zhang HX, Li XL, Cao ZR, Wang KR.
J Med Chem (2021) 64 : 5863 -5873
PubMed 33886333 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 4 7.35 7.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5090920 1 7.77
CHEMBL5078012 1 6.92
CHEMBL1561 MIGLITOL 4.0 1 -
CHEMBL5077606 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5090920 Kd = 17.0 nM 7.77
CHEMBL5078012 Kd = 120.0 nM 6.92
CHEMBL1561 MIGLITOL Kd = 105130.0 nM -
CHEMBL5077606 Kd = 277320.0 nM -