Assay Detail
Binding
CHEMBL5029296
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PIK3C2B (unknown origin) assessed as reduction in substrate phosphorylation by FRET Adapta assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (CHEMBL5554) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.87 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5091438 | — | — | 1 | 9.10 |
| CHEMBL5077865 | — | — | 1 | 9.00 |
| CHEMBL4558527 | AZD-8154 | 2.0 | 1 | 8.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5091438 | — | IC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL5077865 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4558527 | AZD-8154 | IC50 | = | 3.162 | nM | 8.50 |