Assay Detail
Binding
CHEMBL5029453
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Binding affinity to human BRD4 bromodomain 1 assessed as dissociation constant by ITC assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 5.76 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3752296 | — | — | 1 | 6.00 |
| CHEMBL5085444 | — | — | 1 | 5.93 |
| CHEMBL5076790 | — | — | 1 | 5.55 |
| CHEMBL5076935 | — | — | 1 | 5.54 |
| CHEMBL5085843 | — | — | 1 | - |
| CHEMBL5089448 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3752296 | — | Kd | = | 1010.0 | nM | 6.00 |
| CHEMBL5085444 | — | Kd | = | 1170.0 | nM | 5.93 |
| CHEMBL5076790 | — | Kd | = | 2820.0 | nM | 5.55 |
| CHEMBL5076935 | — | Kd | = | 2900.0 | nM | 5.54 |
| CHEMBL5085843 | — | Kd | - | — | - | |
| CHEMBL5089448 | — | Kd | - | — | - |