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Assay Detail

CHEMBL5029588

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human SK-BR-3 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-BR-3
Confidence 1 — Organism
Curated By Autocuration

Target

SK-BR-3 (CHEMBL613834)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents.
Chen H, Deng S, Albadari N, Yun MK, Zhang S, Li Y, Ma D, Parke DN, Yang L, Seagroves TN, White SW, Miller DD, Li W.
J Med Chem (2021) 64 : 12049 -12074
PubMed 34378386 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 7.91 8.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5080238 1 8.72
CHEMBL5094651 1 8.62
CHEMBL5082999 1 8.49
CHEMBL5082677 1 8.46
CHEMBL5081488 1 8.42
CHEMBL4468642 1 8.39
CHEMBL4473244 1 8.38
CHEMBL5091594 1 8.38
CHEMBL5075091 1 8.35
CHEMBL5081479 1 8.32
CHEMBL5092210 1 8.26
CHEMBL5077444 1 8.26
CHEMBL5070361 1 8.15
CHEMBL5089211 1 8.00
CHEMBL5077556 1 7.92
CHEMBL5091955 1 7.82
CHEMBL5084532 1 7.77
CHEMBL5078892 1 7.77
CHEMBL5077762 1 7.59
CHEMBL5074758 1 7.57
CHEMBL5078951 1 7.46
CHEMBL5085733 1 7.34
CHEMBL5092975 1 7.28
CHEMBL5092197 1 7.26
CHEMBL5093354 1 7.24
CHEMBL5088116 1 7.18
CHEMBL5085706 1 7.08
CHEMBL5082985 1 6.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5080238 IC50 = 1.9 nM 8.72
CHEMBL5094651 IC50 = 2.4 nM 8.62
CHEMBL5082999 IC50 = 3.2 nM 8.49
CHEMBL5082677 IC50 = 3.5 nM 8.46
CHEMBL5081488 IC50 = 3.8 nM 8.42
CHEMBL4468642 IC50 = 4.1 nM 8.39
CHEMBL4473244 IC50 = 4.2 nM 8.38
CHEMBL5091594 IC50 = 4.2 nM 8.38
CHEMBL5075091 IC50 = 4.5 nM 8.35
CHEMBL5081479 IC50 = 4.8 nM 8.32
CHEMBL5092210 IC50 = 5.5 nM 8.26
CHEMBL5077444 IC50 = 5.5 nM 8.26
CHEMBL5070361 IC50 = 7.1 nM 8.15
CHEMBL5089211 IC50 = 10.1 nM 8.00
CHEMBL5077556 IC50 = 12.0 nM 7.92
CHEMBL5091955 IC50 = 15.2 nM 7.82
CHEMBL5084532 IC50 = 17.1 nM 7.77
CHEMBL5078892 IC50 = 16.9 nM 7.77
CHEMBL5077762 IC50 = 25.6 nM 7.59
CHEMBL5074758 IC50 = 26.7 nM 7.57
CHEMBL5078951 IC50 = 35.0 nM 7.46
CHEMBL5085733 IC50 = 46.1 nM 7.34
CHEMBL5092975 IC50 = 52.3 nM 7.28
CHEMBL5092197 IC50 = 54.5 nM 7.26
CHEMBL5093354 IC50 = 57.6 nM 7.24
CHEMBL5088116 IC50 = 65.6 nM 7.18
CHEMBL5085706 IC50 = 82.9 nM 7.08
CHEMBL5082985 IC50 = 119.3 nM 6.92