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Compound Detail

CHEMBL5085706

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COc1cc(-n2ccc3ccc(-c4ccc(C)cc4)nc32)cc(OC)c1OC

Basic Information

ChEMBL ID CHEMBL5085706
Phase Preclinical
Structure Type MOL
InChI Key WVCNEPYHFWQIHB-UHFFFAOYSA-N
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

374.4
MW (Da)
5.03
ALogP
5
HBA
0
HBD
45.5
PSA (Ų)
0.49
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H22N2O3
MW 374.44
Aromatic Rings 4
Heavy Atoms 28
NP-Likeness -0.79

Activity Summary

IC50 6 meas. best 7.12

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
M14
CHEMBL614317
IC50 7.12 7.12 76.5 1
SK-BR-3
CHEMBL613834
IC50 7.08 7.08 82.9 1
MDA-MB-453
CHEMBL614334
IC50 6.86 6.86 139.3 1
A-375
CHEMBL613859
IC50 6.76 6.76 174.5 1
RPMI-7951
CHEMBL612447
IC50 6.69 6.69 204.9 1
MDA-MB-231
CHEMBL400
IC50 6.29 6.29 514.7 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine